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A Multifunctional MXene-Fe Composite Microneedle System for Phase-Specific Periodontitis Therapy.
Dan He1,2, Siqi Ye1,2, Yongjin Zhong1,2
1State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu, 610041, China.
Advanced Healthcare Materials
|November 7, 2025
Summary
This study introduces a novel microneedle system for periodontitis treatment. It effectively eradicates biofilms and promotes tissue regeneration using MXene-Fe2O3 nanocomposites and near-infrared light.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Periodontology
Background:
- Periodontitis treatment faces challenges in biofilm eradication and tissue regeneration.
- Microneedles offer a minimally invasive delivery route for deep periodontal sites.
Purpose of the Study:
- To develop a phase-specific microneedle system for periodontitis therapy.
- To utilize MXene-Fe2O3 nanocomposites for synergistic antibacterial and regenerative effects.
Main Methods:
- Fabrication of hyaluronic acid-based microneedles loaded with MXene-Fe2O3 nanocomposites (FM-MN).
- Application of near-infrared (NIR) irradiation for photothermal and ferroptosis-like bacterial death.
- Evaluation of anti-inflammatory and osteogenic properties, including RNA sequencing.
- Testing in a rat periodontitis model.
Main Results:
- FM-MN demonstrated synergistic antibacterial action against biofilms via photothermal and ferroptosis-like mechanisms.
- The system promoted tissue regeneration by scavenging reactive oxygen species, modulating inflammation, and enhancing osteogenic differentiation.
- FM-MN significantly reduced inflammation and restored alveolar bone in vivo.
Conclusions:
- The developed FM-MN system provides a dual-action strategy for periodontitis treatment.
- This microneedle platform offers a versatile approach for complex conditions requiring sequential therapies.
