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A Multifunctional MXene-Fe Composite Microneedle System for Phase-Specific Periodontitis Therapy.

Dan He^1,2, Siqi Ye^1,2, Yongjin Zhong^1,2

¹State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu, 610041, China.

Advanced Healthcare Materials

|November 7, 2025

Summary

This study introduces a novel microneedle system for periodontitis treatment. It effectively eradicates biofilms and promotes tissue regeneration using MXene-Fe2O3 nanocomposites and near-infrared light.

Keywords:

MXene ferroptosis‐like death microneedle periodontitis

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Area of Science:

Biomaterials Science
Nanotechnology
Periodontology

Background:

Periodontitis treatment faces challenges in biofilm eradication and tissue regeneration.
Microneedles offer a minimally invasive delivery route for deep periodontal sites.

Purpose of the Study:

To develop a phase-specific microneedle system for periodontitis therapy.
To utilize MXene-Fe2O3 nanocomposites for synergistic antibacterial and regenerative effects.

Main Methods:

Fabrication of hyaluronic acid-based microneedles loaded with MXene-Fe2O3 nanocomposites (FM-MN).
Application of near-infrared (NIR) irradiation for photothermal and ferroptosis-like bacterial death.
Evaluation of anti-inflammatory and osteogenic properties, including RNA sequencing.
Testing in a rat periodontitis model.

Main Results:

FM-MN demonstrated synergistic antibacterial action against biofilms via photothermal and ferroptosis-like mechanisms.
The system promoted tissue regeneration by scavenging reactive oxygen species, modulating inflammation, and enhancing osteogenic differentiation.
FM-MN significantly reduced inflammation and restored alveolar bone in vivo.

Conclusions:

The developed FM-MN system provides a dual-action strategy for periodontitis treatment.
This microneedle platform offers a versatile approach for complex conditions requiring sequential therapies.