TyG × waist circumference composite indicator and cardiovascular disease risk in older adults across multiple regions: a cross-sectional study
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View abstract on PubMed
Summary
This summary is machine-generated.The triglyceride-glucose index combined with waist circumference (TyG×WC) is a strong predictor of cardiovascular disease (CVD) risk in older adults. Higher TyG×WC levels significantly increase CVD risk, especially in women, aiding in early detection and prevention strategies.
Area Of Science
- Cardiology
- Metabolic Syndrome
- Public Health
Background
- Cardiovascular disease (CVD) remains a leading cause of mortality globally.
- Identifying novel risk factors and predictive markers for CVD is crucial for effective prevention strategies.
- The triglyceride-glucose index (TyG) and waist circumference (WC) are individually associated with metabolic abnormalities and CVD risk.
Purpose Of The Study
- To investigate the association between the triglyceride-glucose index combined with waist circumference (TyG×WC) and cardiovascular disease (CVD) risk in older adults.
- To evaluate the predictive performance and clinical utility of the TyG×WC index for CVD risk assessment.
- To explore potential differences in the association across diverse populations and subgroups.
Main Methods
- Utilized data from three population sources (NHANES, Chinese community cohort, tertiary hospital) totaling 3,443 older adults.
- Calculated the TyG index and combined it with waist circumference (WC) to form the TyG×WC index, categorized into quartiles.
- Employed multivariable logistic regression, ROC curves, NRI, IDI, DCA, and meta-analysis to assess the association, model performance, and clinical utility.
Main Results
- A significant positive association was found between higher TyG×WC quartiles (Q3, Q4) and increased CVD risk (OR = 1.94, 2.47; P<0.001).
- The TyG×WC index demonstrated improved predictive accuracy (AUC, NRI, IDI) compared to models without it.
- A stronger predictive effect was observed in females and within the NHANES population, with consistent trends across populations.
Conclusions
- The TyG×WC composite indicator is an independent predictor of CVD risk in older adults.
- This index enhances CVD risk prediction accuracy and clinical utility, showing strong generalizability.
- TyG×WC serves as a valuable tool for screening high-risk individuals and guiding CVD prevention strategies.
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