Therapeutic Challenges in Metastatic Myxofibrosarcoma: A Case-Based Review.
Trie Arni Djunadi1, Angela Grigos2, Svetoslav Bardarov3
1Internal Medicine, Richmond University Medical Center, Staten Island, USA.
Cureus
|November 7, 2025
Summary
Myxofibrosarcoma (MFS) is an aggressive soft tissue sarcoma with high recurrence rates. This case study explores genetic mutations (NF1, ATM) in a patient with advanced MFS, suggesting potential for targeted therapies.
Area of Science:
- Oncology
- Genetics
- Pathology
Background:
- Myxofibrosarcoma (MFS) is an aggressive soft tissue sarcoma common in elderly individuals, often affecting extremities.
- MFS presents challenges due to high recurrence and metastatic potential despite standard treatments like surgery, radiotherapy, and chemotherapy.


