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Updated: Jan 12, 2026

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Nitroalkenes in directing group-assisted transition-metal-catalyzed C-H functionalization
Wenjing Gao1, Ruirui Song2, Peng Yang1
1Henan Institute of Advanced Technology, Zhengzhou University, Zhengzhou, 450001, P. R. China. yangpeng_imb@zzu.edu.cn.
Abstract:
As an efficient and economical synthetic strategy, transition metal-catalyzed directing group-assisted C-H functionalization has flourished and been widely applied in the synthesis of various functional organic molecules. Among these, selective C-H functionalization involving alkenes has become a common method for constructing carbon-carbon bonds. Nitroalkenes not only exhibit significant pharmacological effects but also possess high reactivity, enabling the concise and rapid synthesis of diverse structural compounds. In recent years, selective C-H functionalization reactions involving nitroalkenes have attracted considerable attention from researchers. Reported works include C-H alkylation, [3+2] cyclization, [4+2] cyclization, and others. This article reviews the applications of nitroalkenes in C-H functionalization reactions, categorized by the reaction type.
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