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  1. Home
  3. Study On The Up-regulated Lncrna Uca1 As Prognostic Biomarker Of Severe Pneumonia And Its Possible Regulatory Mechanism.
  1. Home
  3. Study On The Up-regulated Lncrna Uca1 As Prognostic Biomarker Of Severe Pneumonia And Its Possible Regulatory Mechanism.

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Study on the up-regulated lncRNA UCA1 as prognostic biomarker of severe pneumonia and its possible regulatory

Long Chen1, Ying Chen2, Yuan Yuan1

  • 1North Sichuan Medical College, Nanchong, Sichuan, China.

Biomarkers in Medicine
|November 7, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

Elevated urothelial cancer-associated 1 (UCA1) in children with severe pneumonia indicates poor prognosis and aids diagnosis. UCA1 may regulate cell function and inflammation by interacting with miR-185-5p.

Keywords:
MiR-185-5pSevere pneumoniaUCA1apoptosisinflammationprognosisproliferation

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Area of Science:

  • Pediatric Pulmonology
  • Molecular Biology
  • Biomarker Discovery

Background:

  • Severe pneumonia poses a significant health risk to children worldwide.
  • Identifying reliable biomarkers for diagnosis and prognosis is crucial for effective management.
  • Urothelial cancer-associated 1 (UCA1) is a long non-coding RNA with emerging roles in various diseases.

Purpose of the Study:

  • To investigate the expression levels of UCA1 in children diagnosed with severe pneumonia.
  • To evaluate the diagnostic and prognostic value of UCA1 in pediatric severe pneumonia.
  • To explore the potential regulatory mechanism of UCA1 involving microRNA interactions.

Main Methods:

  • Quantitative real-time PCR was used to measure serum UCA1 levels in 84 children with severe pneumonia and 78 healthy controls.
  • Receiver operating characteristic (ROC) curve analysis assessed diagnostic accuracy.
  • Kaplan-Meier survival analysis and Cox regression identified prognostic factors.
  • Luciferase reporter assays examined the interaction between UCA1 and miR-185-5p.

    • Main Results:

    • Serum UCA1 levels were significantly higher in children with severe pneumonia compared to healthy controls.
    • UCA1 demonstrated high diagnostic accuracy with 82.1% sensitivity and 85.9% specificity.
    • Elevated UCA1 expression correlated with lower overall survival, identifying UCA1 and procalcitonin as risk factors.
    • In vitro studies indicated UCA1 inhibition reversed LPS-induced negative effects on cell viability and inflammation.

    Conclusions:

    • Abnormally elevated serum UCA1 is a valuable biomarker for diagnosing severe pneumonia in children.
    • UCA1 serves as a significant prognostic indicator, with higher levels predicting poorer outcomes.
    • UCA1 may influence cellular functions and inflammatory responses through its interaction with miR-185-5p.