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Role of ubiquitin‑proteasome system in preeclampsia (Review)

Chang-Zhu Pei1, Xiao-Xing Song1, Hao Xu1

  • 1Department of Gynecology, Lianyungang Maternal and Child Health Hospital, Lianyungang, Jiangsu 222000, P.R. China.

Molecular Medicine Reports
|November 7, 2025
PubMed

Insights

Preeclampsia involves abnormal protein regulation via ubiquitination and deubiquitination. Targeting these processes offers new therapeutic strategies for this pregnancy disorder.

Area of Science:

  • Reproductive biology
  • Molecular biology
  • Biochemistry

Background:

  • Preeclampsia (PE) is a pregnancy disorder marked by hypertension and proteinuria.
  • It stems from placental issues and endothelial dysfunction.
  • Ubiquitination and deubiquitination are key post-translational modifications.

Purpose of the Study:

  • To review the role of ubiquitination and deubiquitination in preeclampsia pathogenesis.
  • To explore novel therapeutic strategies targeting the ubiquitin-proteasome system for PE.

Main Methods:

  • Literature review focusing on ubiquitination/deubiquitination pathways in PE.
  • Analysis of the impact of these modifications on trophoblast function.
  • Examination of emerging therapeutic approaches.

Main Results:

  • Dysregulation of ubiquitination and deubiquitination pathways impairs trophoblast function.
  • These pathways are critical in the development of preeclampsia.
  • Targeting the ubiquitin-proteasome system shows therapeutic potential.

Conclusions:

  • Ubiquitination and deubiquitination are crucial in preeclampsia.
  • Targeting these mechanisms offers promising therapeutic avenues.
  • Further research may yield novel interventions for improved maternal and fetal outcomes.

Keywords:
DUBTACPEPROTACdeubiquitinationubiquitin ligase

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