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Updated: Jan 12, 2026
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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Synthesis of 5-Aminooxazoles and Zwitterionic Fused Imidazolones by I2-Mediated C-H Amination
Manman Wang1, Yanliang Liu1, Qingan Xiong1
1College of Material and Chemical Engineering, Zhengzhou University of Light Industry, Zhengzhou 450001, People's Republic of China.
Abstract:
Iodine-mediated C-H amination reactions of β-ketoamides with alkylamines have been developed under transition-metal-free conditions. In the presence of Na2CO3 as the base, I2-promoted annulation of β-ketoamides with benzylamines produces 5-aminooxazole derivatives. Replacement of arylmethylamines with tetrahydroisoquinolines leads to the formation of novel zwitterionic fused imidazolone products. The synthetic protocols are operationally simple and can be conveniently conducted on a gram scale.
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