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Exploring Recurrence Patterns of Esophageal Carcinoma Post-Curative Resection: a Comprehensive Study from a
Amitabha Mandal1, Rohan Kapoor1, Sandeep Bhoriwal1
1Department of Surgical Oncology, Dr. BRA-IRCH, All India Institute of Medical Sciences, New Delhi, Ansari Nagar, 110029, India.
Journal of Gastrointestinal Cancer
|November 7, 2025
Summary
Recurrence after esophagectomy for esophageal cancer is common, with systemic recurrence most frequent. Poor response to neoadjuvant therapy and pathological features predict recurrence, guiding tailored surveillance strategies.
Area of Science:
- Oncology
- Surgical Oncology
- Gastroenterology
Background:
- Esophageal cancer presents a significant oncological challenge with high recurrence rates post-curative resection.
- Understanding recurrence patterns is crucial for optimizing patient management and survival outcomes.
Purpose of the Study:
- To evaluate locoregional and systemic recurrence patterns following curative esophagectomy for esophageal cancer.
- To identify clinical and pathological predictors of recurrence to inform surveillance and treatment strategies.
Main Methods:
- Retrospective analysis of 314 patients with esophageal cancer undergoing curative esophagectomy.
- Inclusion of clinical, pathological, and treatment data from January 2012 to January 2020.
- Statistical analysis including univariate and multivariate methods to identify prognostic factors.
Main Results:
- Overall recurrence rate was 30.9%, with systemic recurrence (12.1%) more common than locoregional (8.0%).
- Frequent recurrence sites included the liver (47%), lungs (34%), and mediastinal nodes (30%).
- Independent predictors of recurrence were poor neoadjuvant therapy response, perineural invasion, and advanced disease stage.
Conclusions:
- Recurrence post-esophagectomy is multifactorial, influenced by tumor biology and treatment response.
- Identifying high-risk patients through neoadjuvant therapy response and pathology enables personalized surveillance and treatment.
- Tailored approaches can potentially improve outcomes for patients with esophageal cancer.
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