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Chlorhexidine 0.02% treatment for refractory blepharoconjunctivitis.

Eran Greenbaum^1,2, Arie Nemet^3,4, Fani Segev⁵

¹Department of Ophthalmology, Meir Medical Center, Affiliated to Tel Aviv University, Kfar Saba, Israel. erangrnb@gmail.com.

Graefe'S Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie

|November 7, 2025

Summary

Twice-daily 0.02% chlorhexidine effectively treated chronic blepharoconjunctivitis in a case series. Patients experienced significant symptom relief and clinical improvement, demonstrating a safe and effective treatment option.

Keywords:

Blepharoconjunctivitis Chlorhexidine

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Area of Science:

Ophthalmology
Microbiology

Background:

Chronic blepharoconjunctivitis can be resistant to standard treatments.
Bacterial infections, particularly Staphylococcus species, are often implicated.

Purpose of the Study:

To evaluate the efficacy and safety of 0.02% chlorhexidine for chronic refractory blepharoconjunctivitis.

Main Methods:

A case series of 10 patients with chronic, treatment-resistant blepharoconjunctivitis.
Treatment involved twice-daily application of 0.02% chlorhexidine.
Clinical signs, symptoms, and cultures were monitored.

Main Results:

60% of patients had positive cultures for antibiotic-resistant Staphylococcus.
Complete resolution of conjunctival hyperemia and substantial symptom improvement occurred within 2 weeks.
Full symptom resolution was reported at 1-month follow-up.

Conclusions:

0.02% chlorhexidine is a safe and effective treatment for chronic, resistant blepharoconjunctivitis.
This treatment offers significant symptomatic and clinical benefits.