Related Experiment Video
Updated: Jan 6, 2026
![Radiosynthesis of 1-2-[18F]Fluoroethyl-L-Tryptophan using a One-pot, Two-step Protocol](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F63025.jpg&w=3840&q=50)
Radiosynthesis of 1-2-[18F]Fluoroethyl-L-Tryptophan using a One-pot, Two-step Protocol
Published on: September 21, 2021
Tryptophan Metabolism in Obesity: Pathways, Mechanisms, and Therapeutic Perspectives
1Department of Cellular and Molecular Nutrition, Faculty of Nutrition Science and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, 1981619573, Iran. ghazaleh_shimi@yahoo.com.
None:
Obesity is a common noncommunicable disease characterized by persistent low-grade chronic inflammation and is associated with various metabolic disturbances, including insulin resistance and diabetes. The search for effective obesity treatments has led to growing interest in the role of amino acids in metabolic regulation. Tryptophan (TRP), an essential amino acid, participates in several biological pathways, including the kynurenine, 5-hydroxytryptamine (5-HT, also known as serotonin), and indole pathways. Recent evidence underscores the significance of TRP metabolism in obesity, showing that various metabolites and enzymes in its metabolic pathways are altered in individuals with obesity. These changes influence physiological processes, mood regulation, and overall metabolic health. This review provides a comprehensive overview of TRP metabolism. It highlights the potential of targeting TRP metabolism as a therapeutic strategy for managing obesity and its related metabolic and psychological comorbidities.
More Related Videos
11:06Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia
Published on: April 7, 2023
09:31PCR Mutagenesis, Cloning, Expression, Fast Protein Purification Protocols and Crystallization of the Wild Type and Mutant Forms of Tryptophan Synthase
Published on: September 26, 2020
Related Concept Videos
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion
Antidepressant Drugs: MAOIs and Other Agents
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution
Amino Acid Biosynthetic Pathways
Antidepressant Drugs: Overview
Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs