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Isotropic Hyperfine Interactions Drive Cross-Effect Dynamic Nuclear Polarization.

Nitzan Livni1, Subhradip Paul2,3, Ilia B Moroz1

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|November 7, 2025
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Summary
This summary is machine-generated.

This study introduces a new method for dynamic nuclear polarization (DNP) using isotropic interactions to enhance solid-state NMR sensitivity. This approach improves efficiency and broadens the applicability of DNP in materials science.

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Area of Science:

  • Solid-state Nuclear Magnetic Resonance (ssNMR) Spectroscopy
  • Dynamic Nuclear Polarization (DNP)

Background:

  • Solid-state NMR spectroscopy suffers from low sensitivity, limiting its applications.
  • Dynamic Nuclear Polarization (DNP) enhances ssNMR sensitivity by transferring electron spin polarization to nuclear spins.
  • The most efficient DNP mechanism in solids, cross-effect (CE), typically requires specific anisotropic electron spin interactions.

Purpose of the Study:

  • To present an alternative approach for achieving the cross-effect (CE) condition in DNP using isotropic interactions.
  • To make CE-DNP independent of sample orientation and MAS frequency.
  • To enable the use of fast-relaxing polarizing agents in DNP experiments.

Main Methods:

  • Utilizing isotropic hyperfine interactions between electron spins and nuclear spins.
  • Employing Mn(II) dopants as polarizing agents.
  • Conducting experimental and simulation-based feasibility studies.

Main Results:

  • Demonstrated that isotropic interactions can fulfill the CE condition for DNP.
  • Achieved DNP enhancements independent of sample orientation and MAS frequency.
  • Showcased the use of Mn(II) dopants and their isotropic hyperfine interactions with 55Mn.

Conclusions:

  • The proposed method offers a novel and versatile route for cross-effect DNP.
  • This approach enhances the practicality and efficiency of DNP in solid-state NMR.
  • The findings pave the way for broader applications of DNP in various scientific fields.