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A Multicomponent Salmon PDRN/Sodium Alginate/Gelatin Hydrogel Promotes Infected Wound Repair in Rat
Yanwen Zhao1, Yu Wang1, Wenlong Sheng1
1Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, Shandong Province 250103, China.
ACS Applied Bio Materials
|November 7, 2025
Summary
A novel hydrogel, GOP, effectively treats infected wounds by reducing inflammation and promoting healing. This innovative material shows antibacterial, antioxidant, and biocompatible properties for advanced wound management.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Wound Healing Research
Background:
- Infected wound healing presents challenges due to excessive inflammation.
- Developing advanced wound dressings is crucial for effective treatment.
Purpose of the Study:
- To synthesize and characterize a novel multicomponent hydrogel (GOP) for infected wound management.
- To evaluate the efficacy of GOP hydrogel in promoting infected wound healing.
Main Methods:
- GOP hydrogel synthesized using salmon polydeoxyribonucleotide (PDRN), oxidized sodium alginate (OSA), and gelatin (Gel) via Schiff-base cross-linking.
- In vitro assessments included antibacterial, antioxidant, biocompatibility, and cell migration assays.
- In vivo studies utilized a murine full-thickness dermal injury model, with histological and immunofluorescence analyses.
Main Results:
- GOP hydrogel exhibited good mechanical properties, tissue adhesion, antibacterial activity against S. aureus and E. coli, and antioxidant capacity.
- In vitro tests showed high cell viability (>80%), promoted cell migration, and minimal hemotoxicity (<2.1%).
- In vivo, GOP treatment significantly reduced residual wound area, decreased inflammation, enhanced collagen deposition, and improved angiogenesis.
Conclusions:
- Hydrogel GOP demonstrates multifunctional properties suitable for infected wound management.
- GOP hydrogel shows potential as a promising therapeutic dressing for accelerating wound healing.
- The study highlights GOP's ability to modulate inflammatory responses and promote tissue regeneration.
