Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integrating Transcription Factors with Electrochemical Pendulum Bioanalysis for Hormone Detection.

Journal of the American Chemical Society·2026
Same author

Biomolecular Condensates as Protein Degradation Tools for Intracellular Targets.

Nature communications·2026
Same author

Resilient nanostructured bioanalytic microneedle longitudinally monitors preclinical renal and hepatic drug clearance and dysfunction.

Science translational medicine·2026
Same author

MXene-Quantum Dot Heterostructures in the Water-Energy Nexus: Simultaneous Photocatalytic Pollutant Degradation and Electrochemical Energy Storage.

ACS applied materials & interfaces·2026
Same author

Amino acid supplementation enhances in vivo efficacy of lipid nanoparticle-mediated mRNA delivery in preclinical models.

Science translational medicine·2026
Same author

Bioinspired Microphase-Engineered Binders for Silicon Anodes.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same journal

Design Principles for Negative Thermal Expansion in Two-Dimensional Materials.

Accounts of chemical research·2026
Same journal

Main Group Redox Catalysis: New Frontiers with Germanium and Tin.

Accounts of chemical research·2026
Same journal

Taming Irreversibility in sp<sup>2</sup>-Carbon-Conjugated COFs from Polycrystalline Powders to Single Crystals and Thin Films.

Accounts of chemical research·2026
Same journal

Electroactive Imidazolium Ionic Liquids in Organic Synthesis.

Accounts of chemical research·2026
Same journal

Calix[4]resorcinarene-Based Porous Organic Cages: Synthesis and Applications.

Accounts of chemical research·2026
Same journal

Light-Driven Dual Rotary Molecular Motors and Beyond.

Accounts of chemical research·2026
See all related articles

Related Experiment Video

Updated: Jan 12, 2026

Electronic Tongue Generating Continuous Recognition Patterns for Protein Analysis
08:46

Electronic Tongue Generating Continuous Recognition Patterns for Protein Analysis

Published on: September 16, 2014

8.2K

Toward Reagentless and Universal Biomolecular Sensing: Molecular Pendulum-Based Bioanalysis.

Zhenwei Wu1, Scott E Isaacson2, Connor D Flynn2,3

  • 1Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, Illinois 60208, United States.

Accounts of Chemical Research
|November 7, 2025
PubMed
Summary
This summary is machine-generated.

Researchers developed a universal molecular pendulum (MP) sensing platform for continuous, real-time health monitoring. This electrochemical biosensor technology enables reagentless detection of diverse analytes in vivo.

More Related Videos

Rapid Homogeneous Detection of Biological Assays Using Magnetic Modulation Biosensing System
06:58

Rapid Homogeneous Detection of Biological Assays Using Magnetic Modulation Biosensing System

Published on: June 13, 2010

10.0K
Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor
08:22

Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

Published on: February 16, 2018

12.5K

Related Experiment Videos

Last Updated: Jan 12, 2026

Electronic Tongue Generating Continuous Recognition Patterns for Protein Analysis
08:46

Electronic Tongue Generating Continuous Recognition Patterns for Protein Analysis

Published on: September 16, 2014

8.2K
Rapid Homogeneous Detection of Biological Assays Using Magnetic Modulation Biosensing System
06:58

Rapid Homogeneous Detection of Biological Assays Using Magnetic Modulation Biosensing System

Published on: June 13, 2010

10.0K
Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor
08:22

Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

Published on: February 16, 2018

12.5K

Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Biosensing Technology

Background:

  • Continuous monitoring of physiological analytes is crucial for disease diagnosis and management.
  • Existing biosensors face challenges like limited sensor lifetime and difficulty in complex biological environments.
  • Electrochemical biosensors offer potential for real-time in vivo analysis of various targets.

Purpose of the Study:

  • To develop a universal, reagentless continuous monitoring platform for diverse biologically relevant targets.
  • To overcome limitations in current biosensing technologies for long-term health monitoring.
  • To establish a versatile sensing system for in vivo applications.

Main Methods:

  • Introduction and development of the molecular pendulum (MP) sensing approach.
  • Expansion of MP analyte scope to include proteins, viral particles, and small molecules.
  • Integration of diverse target receptors (antibodies, nanobodies, aptamers) and development of an active-reset method for continuous monitoring.
  • Implementation of MP sensors in microneedle platforms for interstitial fluid sampling and in vivo testing.

Main Results:

  • Demonstrated MP sensing for various analytes within physiologically relevant ranges.
  • Achieved continuous protein detection via oscillatory receptor regeneration using the active-reset method.
  • Successfully integrated MP sensors into microneedle platforms for in vivo monitoring.
  • Utilized MP systems to gain insights into physiological mechanisms like inflammation and circadian rhythms.

Conclusions:

  • The molecular pendulum (MP) sensing platform shows high potential as a universal biosensing model.
  • MP technology offers high sensitivity, receptor modularity, and in vivo compatibility for continuous health monitoring.
  • Further expansion of MP sensing is anticipated for advanced bioelectronic interfaces and wearable devices.