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Updated: Jan 12, 2026

Evaluating the Effect of SASP Factors on the Proliferation of Cancer Cells Using a Comparative Analysis of Three Distinct Methodologies
Published on: September 19, 2025
Cellular senescence in precancer lesions and early-stage cancers
Xen Ping Hoi1, Mary M Stangis2, Sarah E Glass3
1Department of Urology, Dr. Mary and Ron Neal Cancer Center, Houston Methodist Research Institute, Houston, TX, USA.
Abstract:
Cellular senescence plays dual roles in precancer lesions: initially serving as a tumor-suppressive barrier within the epithelial compartment and later contributing to a pro-tumoral precancer tissue microenvironment (PreTME) via a sustained, paracrine secretome known as senescent-associated secretory phenotype (SASP). This commentary highlights the role of senescence across various PreTME cell types, explores emerging pharmacologic and lifestyle interception strategies, and outlines current challenges for advancing biomarkers and clinical translation.
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