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Updated: Jan 12, 2026

Dissection of Local Ca2+ Signals in Cultured Cells by Membrane-targeted Ca2+ Indicators
Published on: March 22, 2019
Coordinated Remodeling of Ca2+ Signaling and Intracellular Organelles During Cell Division
Fang Yu1,2, Lama Assaf1,3, Khaled Machaca1,2
1Ca Signaling Group, Research Department, Weill Cornell Medicine Qatar, Qatar Foundation, Education City, Doha, Qatar;
Abstract:
Cell division is essential for organismal growth and development and is associated with changes in signaling dynamics, including Ca2+ signaling, to meet structural, functional, and energetic needs. The process of cell division must ensure equal separation of both the genetic material and cellular organelles. Organelle segregation to the daughter cells is in most cases associated with their remodeling to support equal distribution. Here, we review the concurrent remodeling of organelles and Ca2+ signaling during cell division. Interesting patterns emerge, showing that organelle dynamics, specifically the plasma membrane, endoplasmic reticulum, and mitochondria, underlie Ca2+ signaling remodeling during cell division.
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