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Age-specific profiles and ICU predictors in pediatric plastic bronchitis: A multicenter Chinese cohort study,

Huan He1, Li Qiu1, Hua Yang1

  • 1Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, 610041, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, 610041, China.

Respiratory Medicine
|November 7, 2025
PubMed

Insights

Pediatric plastic bronchitis (PB) is more severe in infants, who have different viral patterns. Influenza, high AST, and longer hospital stays predict ICU admission, requiring age-specific care.

Area of Science:

  • Pediatric Pulmonology
  • Respiratory Medicine
  • Infectious Diseases

Background:

  • Plastic bronchitis (PB) is a rare pediatric respiratory condition.
  • Age-specific clinical profiles and predictors of severe progression are poorly understood.

Purpose of the Study:

  • To characterize age-specific clinical profiles and identify predictors of severe progression in pediatric plastic bronchitis.
  • To analyze demographic, clinical, laboratory, and outcome data across different pediatric age groups with PB.

Main Methods:

  • Multicenter retrospective study of 180 pediatric PB cases (2014-2025).
  • Patients categorized into nursing (0-3 yrs), pre-school (>3-6 yrs), and school-age (≥6 yrs) groups.
  • Multivariate logistic regression used to identify independent risk factors for ICU admission.

Main Results:

  • Infants showed more severe respiratory distress and higher ICU admission rates.
  • Mycoplasma pneumoniae was more common in older children; Human Bocavirus predominated in infants.
  • Prolonged hospitalization, elevated AST, and influenza A/B infection were independent risk factors for ICU admission.

Conclusions:

  • Infants represent a high-risk subgroup for pediatric plastic bronchitis with unique virologic patterns.
  • Influenza infection, elevated AST, and extended hospital stay are key predictors for ICU admission.
  • Age-specific management protocols are crucial for pediatric PB.
Abstract

Keywords:
Clinical featuresICU admissionPediatricPlastic bronchitisRisk factors

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