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Published on: February 17, 2021
Bibliometric analysis of exosomes in skin aging: Key trends and hotspots (2015-2024)
Yan Teng1, Qiong Gao1, Qi Gao1
1Center for Plastic & Reconstructive Surgery, Department of Dermatology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital of Hangzhou Medical College, Hangzhou 310014, PR China.
Background:
Exosomes, as nanosized extracellular vesicles, play a crucial role in regulating cellular communication and mediating biological processes related to skin aging, including oxidative stress, inflammation, and extracellular matrix homeostasis. This study aims to provide a comprehensive overview of the current status, key trends, and hotspots in exosome research focused on skin aging.
Methods:
Bibliometric analysis was performed using CiteSpace (Version 6.4.R1), VOSviewer (Version 1.6.20), and Excel (v2021). Data were collected from the Science Citation Index Expanded of Web of Science Core Collection, covering publications from 2015 to 2024. Analyses included publication trends, country/region distribution, institutional contributions, key journals, influential authors, citation patterns, exosome sources, and research hotspots.
Results:
A total of 165 relevant publications (114 original articles and 51 reviews) were identified, with a significant upward trend in publications since 2020, peaking in 2024. China contributed the largest number of publications (84), followed by South Korea (28) and the USA (20). Shanghai Jiao Tong University (China) was the most productive institution, while International Journal of Molecular Sciences published the highest number of articles in this field. BEHFAR A, GAO W, and PARK JH were the most productive authors, and Shabbir A's 2015 article in Stem Cells and Development had the highest local citation score (532). Human-derived exosomes (80 %) were the primary focus, with adipose (29 %) and skin (26 %) as the main tissue sources. Key research hotspots included "exosomes," "mesenchymal stem cells," "skin aging," "collagen," and emerging themes such as "miRNAs" and "drug delivery."
Conclusion:
Research on exosomes in skin aging has grown rapidly, with China, South Korea, and the USA leading in output and influence. The field is transitioning from basic mechanistic studies to translational applications, with a focus on exosome-mediated regeneration, anti-aging therapies, and drug delivery systems. Future directions should emphasize international collaboration, quality improvement, and exploration of novel exosome sources and mechanisms.
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