Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

2.8K
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
2.8K
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

258
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
258
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

200
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
200

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gender Trends in Authorship Across Neuroradiology Journals (2016-2025).

AJNR. American journal of neuroradiology·2026
Same author

Correction to: 2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.

Circulation·2026
Same author

Correction to: 2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.

Hypertension (Dallas, Tex. : 1979)·2026
Same author

2025 update to European Stroke Organisation (ESO) guideline on blood pressure management in acute ischaemic stroke and intracerebral haemorrhage.

European stroke journal·2026
Same author

Trends and Practice Patterns of International Medical Graduates in the U.S. Neuroradiology Workforce: A National Workforce Study.

AJNR. American journal of neuroradiology·2026
Same author

Correction to: 2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.

Hypertension (Dallas, Tex. : 1979)·2026
Same journal

Direct Oral Anticoagulants versus Aspirin for Prevention of Overt and Covert Cerebral Infarction: A Meta-Analysis.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2026
Same journal

Efficacy of Pharyngeal Balloon Muscle Resistance Treatment in Post-Stroke Dysphagia: A Randomized Controlled Trial.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2026
Same journal

Detection of atrial fibrillation via adhesive single-lead ECG vs. Holter monitoring in embolic stroke of undetermined source: the AVANT-GARDE trial.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2026
Same journal

Predictive value of the waist-to-height ratio and HbA1c product for incident stroke: a stratified analysis by blood pressure status.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2026
Same journal

Safety and efficacy of tirofiban as an adjunct to endovascular thrombectomy in large vessel occlusion stroke: A systematic review and meta-analysis with GRADE assessment.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2026
Same journal

Association of FVH/DWI mismatch with recanalization after mechanical thrombectomy in acute anterior-circulation large-vessel occlusion.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2026
See all related articles

Related Experiment Video

Updated: Jan 12, 2026

Performing Permanent Distal Middle Cerebral with Common Carotid Artery Occlusion in Aged Rats to Study Cortical Ischemia with Sustained Disability
09:11

Performing Permanent Distal Middle Cerebral with Common Carotid Artery Occlusion in Aged Rats to Study Cortical Ischemia with Sustained Disability

Published on: February 23, 2016

23.0K

Extensive ischemic change on stroke presentation is uncommon: A population-based study.

Yasmin N Aziz1, Achala Vagal2, Heidi Sucharew3

  • 1University of Cincinnati, Department of Neurology and Rehabilitation Medicine, Cincinnati, OH, USA.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|November 7, 2025
PubMed
Summary
This summary is machine-generated.

Most acute ischemic stroke patients have a good baseline Alberta Stroke Program Early CT Score (ASPECTS) of 6 or higher. Even severe cases (NIHSS ≥6) often present with ASPECTS ≥6, informing stroke treatment and clinical trial design.

Keywords:
Acute Ischemic StrokeEpidemiologyNeuroradiologyStroke

More Related Videos

Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model
05:32

Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model

Published on: August 11, 2023

2.8K
Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping
10:25

Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping

Published on: September 25, 2019

49.2K

Related Experiment Videos

Last Updated: Jan 12, 2026

Performing Permanent Distal Middle Cerebral with Common Carotid Artery Occlusion in Aged Rats to Study Cortical Ischemia with Sustained Disability
09:11

Performing Permanent Distal Middle Cerebral with Common Carotid Artery Occlusion in Aged Rats to Study Cortical Ischemia with Sustained Disability

Published on: February 23, 2016

23.0K
Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model
05:32

Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model

Published on: August 11, 2023

2.8K
Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping
10:25

Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping

Published on: September 25, 2019

49.2K

Area of Science:

  • Neurology
  • Radiology
  • Public Health

Background:

  • Acute ischemic stroke (AIS) management and outcomes are influenced by the severity of ischemia at presentation.
  • The Alberta Stroke Program Early CT Score (ASPECTS) is crucial for anterior circulation stroke triage.
  • Understanding the population-level distribution of baseline ASPECTS is essential for optimizing stroke care.

Purpose of the Study:

  • To determine the distribution of baseline ASPECTS in a large metropolitan population of AIS patients.
  • To assess the correlation between baseline ASPECTS and stroke severity (NIHSS) within different time windows.

Main Methods:

  • Retrospective analysis of AIS patients from the Greater Cincinnati/Northern Kentucky Stroke Study (2015).
  • Inclusion criteria: anterior circulation AIS within 24 hours of last known normal (LKN), available baseline ASPECTS.
  • Blinded central neuroradiologists assessed ASPECTS; NIHSS ≥6 used as a surrogate for large vessel occlusion.

Main Results:

  • Of 949 anterior circulation AIS patients, 96.9% had an ASPECTS ≥6, with 844 having ASPECTS 9-10.
  • Among patients with NIHSS ≥6, 92.2% had an ASPECTS ≥6.
  • Even in patients with NIHSS ≥6 presenting beyond 6 hours, 86.0% had an ASPECTS ≥6.

Conclusions:

  • The majority of AIS patients presenting within 24 hours have an ASPECTS ≥6.
  • A significant proportion of severe AIS cases (NIHSS ≥6) maintain an ASPECTS ≥6, even in extended time windows.
  • These findings support informed resource allocation and clinical trial design for AIS treatment.