Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

787
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
787
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

2.0K
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.0K
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

4.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.3K
Glucose Homeostasis: Pancreatic Islets and Insulin Secretion01:27

Glucose Homeostasis: Pancreatic Islets and Insulin Secretion

2.1K
The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
Insulin and C-peptide are...
2.1K
SBAR II: Application of SBAR01:14

SBAR II: Application of SBAR

5.6K
SBAR is an effective communication tool used by healthcare professionals to communicate patient information accurately. SBAR stands for Situation, Background, Assessment, and Recommendation. For a better understanding, an example is given below.
SBAR Report from a Nurse to a Health Care Provider
S: "Hello, Dr. Smith. This is Jane, RN, from the Med Surg unit. I am calling to tell you about Ms. White in Room 210, who is experiencing increased pain and redness at her incision site. Her recent...
5.6K
Glucose Transporters01:27

Glucose Transporters

27.1K
Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
27.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An interpretable TimeMIL framework for fNIRS: differential diagnosis between schizophrenia and bipolar disorder.

Frontiers in psychiatry·2026
Same author

Attention problems statistically mediate the association between mobile phone addiction and mental health and procrastination in Chinese college students.

Scientific reports·2026
Same author

Assessment of child-parent dyads' health-related quality of life in learning disorder care: a cross-sectional study in eastern China.

Translational pediatrics·2026
Same author

<i>Lactobacillus johnsonii</i>-Derived Extracellular Vesicles Ameliorate Alcohol-Exacerbated Experimental Autoimmune Prostatitis by Inhibiting M1 Macrophage Polarization.

International journal of nanomedicine·2026
Same author

Allele-specific methylation, and InDels of <i>PmMYB10.5b</i> induced by alternative splicing, participate in regulating the leaf color change in <i>Prunus mume</i> 'Meiren'.

Horticulture research·2026
Same author

Spatiotemporal dynamics of seizure networks: Progressive posterior hippocampal recruitment in mesial temporal lobe epilepsy.

Epilepsia·2026
Same journal

Micro- and nanoplastics as emerging clinical analytes: analytical validation, interpretive uncertainty, and laboratory actionability in human specimens.

Clinica chimica acta; international journal of clinical chemistry·2026
Same journal

Performance of Free Light Chain reagents in the Dutch External Quality Assessment programme over the past 14 years.

Clinica chimica acta; international journal of clinical chemistry·2026
Same journal

CRISPR-Cas12a-based liquid biopsy technology: challenges in large-scale clinical application.

Clinica chimica acta; international journal of clinical chemistry·2026
Same journal

Diagnostic biomarkers, prognostic signatures, and therapeutic resistance: shedding light on the dual role of autophagy in glioblastoma.

Clinica chimica acta; international journal of clinical chemistry·2026
Same journal

Artificial intelligence in diagnostic software: validation, safety, and lifecycle challenges in Europe.

Clinica chimica acta; international journal of clinical chemistry·2026
Same journal

Strategies for effective occurrence Management in Resource-Limited Clinical Laboratories: Challenges and practical solutions.

Clinica chimica acta; international journal of clinical chemistry·2026
See all related articles

Related Experiment Video

Updated: Jan 12, 2026

Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

19.3K

Hyperglycemia in sepsis.

Ting Wang1, Binbin Gong2, Kangjie Shi2

  • 1Taizhou Hospital, Zhejiang University,Taizhou 317000, China; College of Life Science, Zhejiang sci-tech university, Hangzhou 310018, China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|November 7, 2025
PubMed
Summary
This summary is machine-generated.

Sepsis-induced hyperglycemia, a common complication, worsens patient outcomes due to abnormal glucose metabolism and insulin resistance. Understanding these mechanisms is key for effective blood glucose management in sepsis.

Keywords:
Glycemic controlHyperglycemiaMedicineSepsis

More Related Videos

Author Spotlight: Investigating the Blood Glucose Homeostasis in Murine Brain Using a Cost-Effective Hyperglycemic And Hypoglycemic Clamp Technique
07:35

Author Spotlight: Investigating the Blood Glucose Homeostasis in Murine Brain Using a Cost-Effective Hyperglycemic And Hypoglycemic Clamp Technique

Published on: January 26, 2024

2.1K
A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia
09:35

A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia

Published on: November 15, 2024

823

Related Experiment Videos

Last Updated: Jan 12, 2026

Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

19.3K
Author Spotlight: Investigating the Blood Glucose Homeostasis in Murine Brain Using a Cost-Effective Hyperglycemic And Hypoglycemic Clamp Technique
07:35

Author Spotlight: Investigating the Blood Glucose Homeostasis in Murine Brain Using a Cost-Effective Hyperglycemic And Hypoglycemic Clamp Technique

Published on: January 26, 2024

2.1K
A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia
09:35

A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia

Published on: November 15, 2024

823

Area of Science:

  • Critical Care Medicine
  • Endocrinology
  • Pathophysiology

Background:

  • Sepsis is a life-threatening organ dysfunction caused by infection.
  • Hyperglycemia is a frequent complication in sepsis patients.
  • Elevated blood glucose levels are linked to increased mortality in sepsis.

Purpose of the Study:

  • To review the mechanisms of sepsis-induced hyperglycemia.
  • To discuss blood glucose management strategies in sepsis.
  • To explore hypoglycemic drugs for improving sepsis outcomes.

Main Methods:

  • Literature review of sepsis pathophysiology and glycemic control.
  • Analysis of mechanisms driving hyperglycemia in sepsis.
  • Evaluation of clinical data on glucose management and drug efficacy.

Main Results:

  • Hyperglycemia results from counterregulatory hormones, insulin resistance, Warburg effect, and DPP-IV degradation.
  • Poor glycemic control independently predicts worse prognosis in sepsis.
  • Individualized glycemic management is crucial.

Conclusions:

  • Understanding sepsis-induced hyperglycemia mechanisms is vital for clinical practice.
  • Effective blood glucose management can improve sepsis outcomes.
  • Further research into targeted hypoglycemic therapies is warranted.