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Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
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ABCC6-Related Left Ventricular Papillary Muscle Calcification

Lukas Nollet1, Ruben Pauwels2, Julie De Zaeytijd3

  • 1Center for Medical Genetics Ghent, Ghent University Hospital, Ghent, Belgium; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.

JACC. Case Reports
|November 7, 2025
PubMed

Insights

Extensive papillary muscle calcification can indicate Pseudoxanthoma Elasticum (PXE), a rare genetic disorder. This case highlights the importance of genetic testing for cardiovascular calcification when PXE is suspected.

Area of Science:

  • Cardiovascular Medicine
  • Medical Genetics
  • Ophthalmology

Background:

  • Extensive papillary muscle calcification is associated with ischemic heart disease and radiotherapy.
  • Rarely, it can be a manifestation of Mendelian disorders.
  • Pseudoxanthoma Elasticum (PXE) is a rare genetic disorder affecting connective tissue.
Abstract

Keywords:
computed tomographyechocardiographygenetic disorderspapillary muscles

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