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Gene Expression-Based Lesion-Symptom Mapping: FOXP2 and Language Impairments after Stroke
Janina Wilmskoetter1, Sigfus Kristinsson2, Ida Rangus2
1Department of Rehabilitation Sciences, College of Health Professions, Medical University of South Carolina, Charleston, South Carolina 29425.
Summary
Gene-expression lesion-symptom mapping (GLSM) links stroke lesions to gene expression in brain regions. Lesions in areas with high FOXP2 gene expression correlate with worse aphasia severity after stroke.
Area of Science:
- Neuroscience
- Genetics
- Computational Biology
Background:
- Chronic aphasia is a common post-stroke deficit, with lesion location influencing severity.
- Factors beyond lesion location, such as gene expression in affected brain regions, are underexplored in aphasia research.
Purpose of the Study:
- To introduce and validate a novel computational approach, gene-expression lesion-symptom mapping (GLSM).
- To investigate the association between stroke lesion location, FOXP2 gene expression, and aphasia severity.
Main Methods:
- Applied GLSM to a cohort of 91 individuals with chronic aphasia post-left-hemisphere stroke.
- Mapped lesion locations to brain regions with varying FOXP2 gene expression levels.
Main Results:
- Individuals with lesions in language areas exhibiting high FOXP2 expression showed worse aphasia severity.
- FOXP2 gene expression lesion load explained more variance in aphasia severity than lesion load alone.
Conclusions:
- GLSM offers a novel perspective on lesion-symptom relationships in aphasia.
- Findings highlight the neurogenetic underpinnings of post-stroke language impairments and potential for personalized rehabilitation.
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