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CagA-positive Helicobacter pylori may be associated with current infection of clonorchiasis

Chunyi Long1, Ziying Lin2, Jianyu Cao1

  • 1Department of Infection, Guangxi Clinical Medical Research Center for Hepatobiliary Diseases, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, 533000, China.

Scientific Reports
|November 7, 2025
PubMed

Insights

Consuming raw fish and CagA-positive Helicobacter pylori (H. pylori) infection are independent risk factors for Clonorchiasis. CagA-positive H. pylori infection was significantly more prevalent in Clonorchiasis patients compared to healthy individuals.

Area of Science:

  • Infectious Diseases
  • Gastroenterology
  • Parasitology

Background:

  • Clonorchiasis, a parasitic infection, poses significant public health challenges.
  • Helicobacter pylori (H. pylori) infection is a common bacterial infection with known gastrointestinal implications.
  • The interplay between H. pylori, particularly CagA-positive strains, and Clonorchiasis requires further investigation.

Purpose of the Study:

  • To investigate the association between H. pylori infection, specifically CagA-positive strains, and Clonorchiasis.
  • To identify risk factors contributing to Clonorchiasis.
  • To compare the prevalence of H. pylori infection in individuals with and without Clonorchiasis.

Main Methods:

  • Cross-sectional study involving civil servants and hospitalized Clonorchiasis patients.
  • Detection of H. pylori and Clonorchiasis antibodies using ELISA.
  • Western blotting to identify H. pylori strains; multifactorial analysis for risk factors.

Main Results:

  • H. pylori and Clonorchiasis antibody positivity rates were 43.7% and 23.9% in civil servants, respectively.
  • H. pylori infection was more prevalent in Clonorchiasis patients (61.6%) than in healthy controls (44.0%).
  • Consuming raw fish and CagA-positive H. pylori infection were identified as independent risk factors for Clonorchiasis.

Conclusions:

  • CagA-positive H. pylori infection is significantly associated with Clonorchiasis.
  • Dietary habits, such as consuming raw fish, and specific H. pylori strains are crucial risk factors for Clonorchiasis.
  • Findings highlight the importance of considering co-infections and lifestyle factors in managing Clonorchiasis.

Keywords:
CagA-positive Helicobacter pyloriClonorchiasisCurrent infectionImmunity

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