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Published on: April 19, 2024
Duration of noninvasive respiratory support in preterm infants: Association with gestational age and risk factors for
Shu Eguchi1, Tomohiro Takeda2, Atsushi Nakao2
1Department of Neonatology, Japanese Red Cross Medical Center, Tokyo, Japan. ks0eh1nu0te17@gmail.com.
Objective:
To analyze the association between gestational age (GA) and postmenstrual age (PMA) at successful noninvasive respiratory support (NRS) -which includes noninvasive ventilation with neurally adjusted ventilatory assist (NIV-NAVA), nasal continuous positive airway pressure (nCPAP), and high-flow nasal cannula (HFNC)- weaning and to identify the risk factors affecting PMA at successful NRS weaning.
Study Design:
This retrospective cohort study included 449 preterm infants born before 32 weeks' GA who were admitted to the neonatal intensive care unit between 2015 and 2023.
Results:
The median PMA at successful weaning was 36.0 weeks. PMA at successful weaning was negatively correlated with GA. Only a small number of infants with earlier GA achieved successful weaning before 36 weeks of PMA. Earlier GA, small for GA, bubbly/cystic appearance on X-rays, and bowel perforation with ileostomy were identified as risk factors for delayed weaning.
Conclusion:
Clinical interventions should consider these risks to optimize weaning outcomes.
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