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Updated: Jan 12, 2026
Assessment of Child Anthropometry in a Large Epidemiologic Study
Published on: February 2, 2017
Association between serum omentin-1 concentrations and body composition measured by dual-energy X-ray absorptiometry
Yuki Murakami1, Yuki Fujita2, Kumiko Ohara3
1Department of Hygiene and Public Health, Faculty of Medicine, Kansai Medical University, 2-5-1 Shin-Machi, Hirakata, Osaka, 573-1010, Japan. murakami.yk@kmu.ac.jp.
Background:
Omentin-1 (also known as intelectin-1) is a novel adipokine associated with metabolic diseases. However, its physiological role in body composition remains incompletely understood. Therefore, this study aimed to investigate the association between the circulating omentin-1 levels and whole-body and regional body composition parameters measured using dual-energy X-ray absorptiometry (DXA).
Methods:
A population-based cross-sectional survey was conducted among school-aged children in Hamamatsu, Japan. Serum adipokine levels were measured using enzyme-linked immunosorbent assay, and associations between omentin-1 levels and DXA-based parameters were evaluated by multiple regression analysis after adjusting for potential confounding factors.
Results:
The final study included 392 participants (192 boys, 200 girls, 75.2% of the source population; mean age 11.2 ± 0.3 years). Serum omentin-1 levels showed a significantly inverse association with nearly all DXA-based fat mass parameters. Inverse correlations were observed with fat-free soft tissue mass and serum leptin levels, whereas positive correlations were noted with adiponectin levels. The mean values for various body fat parameters, fat-free soft tissue mass, body mass index, and waist circumference were significantly decreased across tertiles of serum omentin-1 levels from lowest to the highest after adjusting for potential confounders.
Conclusion:
Our results demonstrate that Japanese school-aged children with higher fat mass tended to have lower serum omentin-1 levels. These findings provide crucial insights into the link between omentin-1 levels and body composition, which may contribute to early health interventions for metabolic improvement.
