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Severe lymphocytopenia induced by methimazole tablets: A rare case report
Yi Li1, Bo Tan2, Liutao Zheng3
1Department of Pharmacy, Pengzhou Hospital of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Rationale:
Severe lymphocytopenia, febrile granulocytopenia, and leukopenia induced by methimazole (MMI) are extremely rare.
Patient Concerns:
A 26-year-old Han Chinese female with hyperthyroidism was admitted to the hospital with fever and tonsillar enlargement after taking MMI tablets for 1 month. Adverse drug reactions correlation analysis revealed this as a novel severe adverse reaction.
Diagnoses:
The patient was diagnosed with agranulocytosis with fever, thyroid storm, acute suppurative tonsillitis, and mild anemia.
Interventions:
After admission, MMI tablets were discontinued. The patient received granulocyte colony-stimulating factor, Leucogen tablets, Diyu Shengbai tablets to elevate white blood cell count, methylprednisolone sodium succinate for inflammation, and cefuroxime sodium for infection control.
Outcomes:
The patient was discharged after 11 days of clinical treatment.
Lessons:
Through the assessment of adverse drug reactions correlation and analysis of susceptibility factors, we recognized the importance of medication education and demonstrated that changes in clinical practice can save lives.
