Analysis of factors affecting early hepatic steatosis in pediatric patients with Wilson's disease in China: A retrospective study
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View abstract on PubMed
Summary
This summary is machine-generated.In children with Wilson's disease (WD), higher alanine aminotransferase and triglyceride levels are linked to hepatic steatosis. High-density lipoprotein cholesterol showed an inverse relationship, suggesting its protective role.
Area Of Science
- Hepatology
- Pediatric Gastroenterology
- Metabolic Disorders
Background
- Hepatic steatosis is a common early sign of Wilson's disease (WD), especially in children.
- Understanding factors associated with hepatic steatosis in pediatric WD is crucial for early detection and management.
Purpose Of The Study
- To investigate the relationship between demographic factors, biochemical markers, and lipid metabolism with hepatic steatosis in pediatric patients with WD.
- To identify independent predictors of hepatic steatosis in this population.
Main Methods
- Retrospective observational study of 239 pediatric patients with WD.
- Data collection included serological and imaging data to assess hepatic steatosis.
- Multivariable logistic regression analysis was used to identify independent predictors.
Main Results
- Higher alanine aminotransferase (ALT) and triglyceride levels were independently associated with hepatic steatosis.
- High-density lipoprotein cholesterol (HDL-C) showed an inverse association with hepatic steatosis.
- Aspartate aminotransferase (AST) was not a significant predictor after adjustment.
Conclusions
- In pediatric Wilson's disease, elevated ALT and triglycerides are independent predictors of hepatic steatosis.
- Low HDL-C may be protective against hepatic steatosis in this cohort.
- Further prospective validation is needed to confirm these findings for clinical application.
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