Related Experiment Video
Updated: Jan 12, 2026

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
Published on: September 30, 2021
Bibliometric and visual analysis of global research on primary liver cancer from 2014 to 2024
Yanan Wang1,2, Yingying Hui2,3, Chunjiang Cai2
1School of Basic Medical Sciences, Hebei University of Traditional Chinese Medicine, Shijiazhuang, China.
Objective:
To evaluate the quantity and quality of global research on primary liver cancer (PLC) over the past decade, visualize research hotspots, and reveal trends in PLC research.
Methods:
A comprehensive search was conducted in the Web of Science Core Collection for academic publications from January 1, 2014 to January 1, 2024. VOSviewer and CiteSpace were used to analyze and visualize research trends and hotspots.
Results:
A total of 1728 articles from 69 countries were included in the study, with China and the United States being the leading contributors. The number of publications related to primary liver cancer has increased annually. Major research institutions involved in this field include Fudan University, Sun Yat-Sen University, among others. A total of 11,001 authors from around the world have published papers; among them, McGlynn, Kokudo Norihiro, and Kudo Masatoshi published the most articles, while Llovet JM is the most frequently cited author in this field. Frontiers in Oncology is the most popular journal in the field of liver cancer, while Hepatology is the most co-cited journal. In recent years, terms such as "multicenter," "open label," and "safety" have gained increasing attention and development.
Conclusion:
Our findings offer valuable insights and references for the development of key areas in PLC and contribute to future research.
Related Concept Videos
Targeted Cancer Therapies
There are several types of targeted therapies against...
Cancer Survival Analysis
Diseases of the Liver and Gallbladder
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Liver Regeneration
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...

