Related Experiment Video
Updated: Jan 12, 2026
Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
Normobaric hyperoxia as an adjuvant to endovascular treatment in acute ischemic stroke: a systematic review and
Tian Wang1,2, Xiaohan Zhang1, Pingkai Wang1
1Department of Neurology, First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Background:
Normobaric hyperoxia (NBO) has emerged as a potential adjuvant therapy for enhancing cerebral oxygenation and neuroprotection in patients with acute ischemic stroke (AIS). The combination of endovascular treatment (EVT) with NBO may offer synergistic benefits by mitigating ischemic injury and improving tissue reperfusion outcomes. This meta-analysis of randomized controlled trials (RCTs) aimed to evaluate the therapeutic efficacy and safety profile of NBO therapy in AIS patients undergoing EVT.
Methods:
We searched five databases (PubMed, Embase, Cochrane Library, Web of Science, and Scopus) from their inception to 15 March 2025, for RCTs comparing NBO vs. control in EVT-treated AIS. The primary outcomes were 90-day functional independence and all-cause mortality. The safety outcomes comprised symptomatic intracranial hemorrhage (sICH), any intracranial hemorrhage, and early neurological deterioration. Data synthesis was performed using random-effects models. Risk of bias and evidence certainty were assessed with the Cochrane tool and the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach, respectively.
Results:
This meta-analysis incorporated five RCTs comprising 730 patients. The NBO group demonstrated a significant enhancement in 90-day functional independence (RR = 1.27, 95% CI: 1.10-1.47, p = 0.001) and a reduction in mortality (RR = 0.61, 95% CI: 0.40-0.93, p = 0.02). Subgroup analyses revealed that initiating NBO therapy pre-EVT improved functional outcomes (RR = 1.38, 95% CI: 1.13-1.68, p = 0.001), whereas post-EVT NBO administration lowered mortality rates (RR = 0.44, 95% CI: 0.21-0.93, p = 0.03). The safety outcomes, including sICH, any ICH, and early neurological deterioration, did not exhibit significant differences between groups.
Conclusion:
NBO as an adjuvant therapy to EVT improves functional independence and reduces mortality in AIS patients, without an increase in safety risks. These results support the potential integration of NBO into EVT protocols to enhance patient recovery. However, further high-quality, multicenter RCTs are warranted to validate these findings and optimize NBO application.
More Related Videos
14:28Non-Invasive Monitoring of Microvascular Oxygenation and Reactive Hyperemia using Hybrid, Near-Infrared Diffuse Optical Spectroscopy for Critical Care
Published on: May 10, 2024
12:15Optimized System for Cerebral Perfusion Monitoring in the Rat Stroke Model of Intraluminal Middle Cerebral Artery Occlusion
Published on: February 17, 2013
Related Concept Videos
01:16Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
01:18Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
01:23Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
01:17Ischemic Heart Disease: Overview
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
01:27Regulation of Stroke Volume
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
01:30Acute Coronary Syndrome I: Introduction