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Case-Based Applications of the 2025 AHA/ACC/Multispecialty High Blood Pressure Guideline

Natalie A Cameron1,2, Daniel W Jones3, Sadiya S Khan2,4

  • 1Division of General Internal Medicine, Department of Medicine (N.A.C.), Northwestern University Feinberg School of Medicine, Chicago, IL.

Hypertension (Dallas, Tex. : 1979)
|November 8, 2025
PubMed

Insights

This article uses 4 cases to explain the 2025 hypertension guideline for outpatient care. It details a risk-based approach for managing high blood pressure, incorporating updated recommendations for lifestyle, medication, and pregnancy care.

Area of Science:

  • Cardiology and Internal Medicine
  • Public Health and Epidemiology

Background:

  • Hypertension impacts nearly half of US adults and is a leading preventable cause of global cardiovascular disease.
  • An updated 2025 guideline for high blood pressure management has been released by major professional organizations.

Purpose of the Study:

  • To bridge the gap between the 2025 hypertension guideline and individualized patient care.
  • To provide practical guidance for healthcare teams in managing high blood pressure in outpatient settings.

Main Methods:

  • Presentation of 4 hypothetical cases of high blood pressure.
  • Focus on applying a risk-based management approach incorporating blood pressure levels, cardiovascular disease risk factors, and predictive equations.
  • Illustration of notable 2025 guideline updates, including lifestyle, medication, goals, screening, and pregnancy management.

Main Results:

  • The cases demonstrate the practical application of the updated 2025 hypertension guideline.
  • The risk-based approach integrates multiple factors for personalized high blood pressure management.

Conclusions:

  • Contextualizing the 2025 guideline within case scenarios offers practical, evidence-based care strategies.
  • Updated management strategies aim to improve prevention, detection, evaluation, and treatment of high blood pressure.

Keywords:
antihypertensive agentsblood pressurecardiovascular diseaseshypertensionrisk factors

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