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Radiotherapy for penile cancers: 2025 update.

Geneviève Loos1, Alexandre Escande2, Sabrina Aziez3

  • 1Département d'oncologie radiothérapie, centre Jean-Perrin, Clermont-Ferrand, France.

Cancer Radiotherapie : Journal De La Societe Francaise De Radiotherapie Oncologique
|November 8, 2025
PubMed
Summary

This update provides French national guidelines for penile cancer management, emphasizing multidisciplinary care and centralization. Recommendations cover radiotherapy, brachytherapy, sentinel node biopsy for high-risk patients, and organ preservation options.

Keywords:
BrachytherapyCancer de la vergeChemotherapyChimiothérapieChirurgieCuriethérapieManagementPenile cancerRadiotherapyRadiothérapieSurgery

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Area of Science:

  • Oncology
  • Urology
  • Radiation Oncology

Background:

  • Penile cancer is a rare malignancy requiring specialized management.
  • Previous guidelines require updates to reflect current best practices.

Purpose of the Study:

  • To present an updated French national guideline for penile cancer management.
  • To provide recommendations on radiotherapy and brachytherapy for penile cancer.
  • To emphasize the importance of multidisciplinary care and centralization.

Main Methods:

  • Review and synthesis of current evidence and expert consensus.
  • Development of recommendations for diagnosis, staging, and treatment.
  • Inclusion of specific guidance on radiotherapy and brachytherapy parameters.

Main Results:

  • Multidisciplinary management and centralization in expert centers are crucial.
  • Dynamic sentinel node biopsy is recommended for high-risk patients (T1b or higher).
  • Human papillomavirus (HPV) status should be obtained for staging.
  • Organ preservation with brachytherapy should be considered for glans-limited tumors.
  • Chemoradiotherapy may be considered for locoregionally advanced disease.

Conclusions:

  • Updated guidelines promote optimal patient outcomes through standardized, evidence-based care.
  • Centralization and multidisciplinary approaches enhance the management of this rare cancer.
  • Specific recommendations address surgical staging, radiotherapy, brachytherapy, and chemoradiotherapy options.