Radiotherapy for penile cancers: 2025 update

Area of Science:

• Oncology
• Urology
• Radiation Oncology

Background:

• Penile cancer is a rare malignancy requiring specialized management.
• Previous guidelines require updates to reflect current best practices.

Purpose of the Study:

• To present an updated French national guideline for penile cancer management.
• To provide recommendations on radiotherapy and brachytherapy for penile cancer.
• To emphasize the importance of multidisciplinary care and centralization.

Main Methods:

• Review and synthesis of current evidence and expert consensus.
• Development of recommendations for diagnosis, staging, and treatment.
• Inclusion of specific guidance on radiotherapy and brachytherapy parameters.

Main Results:

• Multidisciplinary management and centralization in expert centers are crucial.
• Dynamic sentinel node biopsy is recommended for high-risk patients (T1b or higher).
• Human papillomavirus (HPV) status should be obtained for staging.
• Organ preservation with brachytherapy should be considered for glans-limited tumors.
• Chemoradiotherapy may be considered for locoregionally advanced disease.

Conclusions:

• Updated guidelines promote optimal patient outcomes through standardized, evidence-based care.
• Centralization and multidisciplinary approaches enhance the management of this rare cancer.
• Specific recommendations address surgical staging, radiotherapy, brachytherapy, and chemoradiotherapy options.