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Related Concept Videos

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Treatment Resistant Cancers

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Cancer Therapies02:49

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells
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Radiotherapy for brain metastases: 2025 update.

Delphine Antoni1, Emmanuel Mesny2, Osman El Kabbaj3

  • 1Radiation Oncology Department, Institut de cancérologie Strasbourg Europe, Strasbourg, France.

Cancer Radiotherapie : Journal De La Societe Francaise De Radiotherapie Oncologique
|November 8, 2025
PubMed
Summary

Updated French Society for Radiation Oncology guidelines offer recommendations for managing brain metastases with radiotherapy. These guidelines address complex challenges, aiming for personalized treatment strategies and minimizing side effects for improved patient outcomes.

Keywords:
Brain metastasisCognitionGuidelinesMétastases cérébralesPrognostic scoresRadiothérapie en conditions stéréotaxiquesRecommandationsSFROScores pronostiquesSociété française de radiothérapie oncologiqueStereotactic radiotherapy

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Area of Science:

  • Radiation Oncology
  • Neuro-oncology
  • Medical Imaging

Background:

  • Brain metastases management is increasingly complex due to longer patient survival and advances in systemic therapies.
  • Technological progress in imaging and radiotherapy necessitates updated treatment protocols.
  • Personalized prognostic classifications and the potential for iterative radiotherapy require careful consideration.

Purpose of the Study:

  • To present updated recommendations from the French Society for Radiation Oncology (SFRO) on brain metastases radiotherapy.
  • To outline indications and technical modalities for radiotherapy in brain metastases management.
  • To emphasize the importance of multidisciplinary and personalized therapeutic strategies.

Main Methods:

  • Review and synthesis of current evidence and clinical expertise by the SFRO.
  • Development of updated guidelines based on prognostic classifications and treatment advancements.
  • Focus on integrating radiotherapy with systemic therapies and managing side effects.

Main Results:

  • Established updated indications for radiotherapy in patients with brain metastases.
  • Defined technical radiotherapy modalities, including dose fractionation and delivery techniques.
  • Highlighted the need for individualized treatment planning and follow-up.

Conclusions:

  • Radiotherapy remains a cornerstone in the management of brain metastases.
  • Personalized, multidisciplinary strategies are crucial for optimizing efficacy and minimizing toxicity.
  • Recommendations emphasize adapting treatment based on disease evolution and patient status.