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Updated: Jan 11, 2026

An Olfactory Preference Test for Measuring Olfactory Hedonic Biases in Mouse Models of Depression
Published on: July 11, 2025
Odor Hedonic Profile (OHP): A sensitive tool in depressive populations
Boriana Atanasova1, François Kazour2, Wissam El-Hage1
1Université de Tours, INSERM, Imaging Brain & Neuropsychiatry iBraiN U1253, 37032 Tours, France.
Aim:
The aim of the present study was to assess the Odor Hedonic Profile (OHP) to evaluate its sensitivity in relation to the level of depression.
Method:
The self-rating tool (OHP) related to everyday odors and recently validated in the general population is based on hedonic estimation without olfactory stimulation to avoid bias linked to odorant properties and experimental protocols. OHP scores in a population with a major depressive episode were compared to a non-depressed control population and a population with a moderate depressive state.
Results:
The results showed significant differences in OHP scores depending on the group of participants (depressed, moderately depressed, and control). The results also showed that significant differences in OHP scores are related to sex. In addition, the results showed that OHP scores were correlated with levels of depression, anxiety and pleasure experienced. Finally, the group of depressed participants showed more conservative and negative aliesthesia profiles than moderately depressed and non-depressed control participants.
Discussion:
This study shows that OHP can be used in different populations, especially in diseases with mood/emotional disturbances such as depression.
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