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Updated: Jan 11, 2026

An Olfactory Preference Test for Measuring Olfactory Hedonic Biases in Mouse Models of Depression
Published on: July 11, 2025
Odor Hedonic Profile (OHP): A sensitive tool in depressive populations
Boriana Atanasova1, François Kazour2, Wissam El-Hage1
1Université de Tours, INSERM, Imaging Brain & Neuropsychiatry iBraiN U1253, 37032 Tours, France.
The Odor Hedonic Profile (OHP) effectively differentiates depression levels, showing distinct scent perception in depressed individuals. This tool aids in understanding mood disorders through olfactory responses.
Area of Science:
- Neuroscience
- Psychology
- Sensory Science
Background:
- Depression significantly impacts emotional and sensory processing.
- Olfactory perception is closely linked to emotional states and memory.
- Existing diagnostic tools may not fully capture sensory alterations in depression.
Purpose of the Study:
- To evaluate the Odor Hedonic Profile (OHP) as a sensitive measure for depression.
- To compare OHP scores across depressed, moderately depressed, and non-depressed individuals.
- To explore the relationship between OHP, depression severity, anxiety, and pleasure.
Main Methods:
- Utilized the Odor Hedonic Profile (OHP), a self-rating tool for everyday odors.
- OHP employs hedonic estimation without direct olfactory stimulation to minimize bias.
- Compared OHP scores between a major depressive episode group, a moderate depressive state group, and a control group.
Main Results:
- Significant differences in OHP scores were observed across the three participant groups (depressed, moderately depressed, control).
- OHP scores showed significant correlations with depression, anxiety, and experienced pleasure levels.
- Depressed participants exhibited more conservative and negative aliesthesia profiles compared to other groups.
Conclusions:
- The Odor Hedonic Profile (OHP) demonstrates utility in assessing individuals with mood and emotional disturbances, particularly depression.
- OHP can be a valuable tool for research and clinical applications in psychiatric populations.
- This study highlights the potential of sensory assessment in understanding the multifaceted nature of depression.
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