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Persistent oxidative stress and functional outcomes in early psychosis: A longitudinal study
M Ćelić Ružić1, N Žarković2, L Rossini Gajšak1
1Clinic for Psychiatry "Sveti Ivan", Jankomir 11, 10090 Zagreb, Croatia; Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Crkvena 21, 31000 Osijek, Croatia.
Psychiatry Research
|November 9, 2025
Summary
Patients with acute psychosis exhibit persistent oxidative imbalance, with lower antioxidative capacity linked to negative symptoms. This redox dysregulation may be a stable trait, suggesting new therapeutic targets.
Area of Science:
- Neuroscience
- Biochemistry
- Psychiatry
Background:
- Oxidative stress is implicated in psychosis pathophysiology.
- Understanding redox balance in early psychosis is crucial for treatment.
Purpose of the Study:
- Evaluate oxidative stress markers (TOC, TAC, 4-HNE) in acute psychosis.
- Assess changes after treatment and their correlation with clinical outcomes.
Main Methods:
- Prospective cohort study of 122 male patients with psychotic disorders and 102 controls.
- Clinical assessment using PANSS, SANS, GAF, FROGS, and QLS-5.
Main Results:
- Patients showed higher TOC/4-HNE and lower TAC than controls.
- Lower TAC correlated with more severe negative symptoms.
- Oxidative markers remained unchanged post-treatment despite clinical improvement.
Conclusions:
- Early psychosis features persistent oxidative imbalance, suggesting a trait-like redox dysregulation.
- Biomarkers could aid in understanding disease mechanisms and monitoring outcomes.
- Targeting redox processes may enhance psychosis treatment.
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