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Use of Nebulized Tranexamic Acid (TA) in Combination With Nebulized Recombinant Coagulation Factor VIIa to Treat
Santosh Yatam Ganesh1, Nelda Itzep2, Eduardo Bruera1
1Division of Cancer Medicine (S.Y.G., E.B.), Palliative, Rehabilitation, and Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Abstract:
Hemoptysis is a distressing symptom for both patients and families at end of life (EOL). In the acute care setting, this can be managed surgically or medically. However, research regarding interventions, such as nebulized tranexamic acid (TA) and nebulized factor VIIa, for palliative management of hemoptysis at EOL is limited. In our case series, we found that combination of nebulized recombinant factor VIIa and nebulized TA relieved hemoptysis in both pediatric cancer patients at the end of life. This case series highlights the potential use of this combination to reduce suffering and distress secondary to hemoptysis in the palliative setting.
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