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Decoding the peripheral neuro-immune Axis: A new frontier in disease therapy
Naonao Yuan1, Yanping Lin2, Zhibo Ma1
1Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, PR China; Key Laboratory of Organ Transplantation, Ministry of Education; NHC Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, 430030 Wuhan, PR China.
The peripheral nervous system (PNS) and immune system communicate extensively, influencing health and disease. Understanding this neuroimmune axis offers new therapeutic targets for various conditions.
Area of Science:
- Neuroscience
- Immunology
- Physiology
Background:
- The peripheral nervous system (PNS) and immune system are closely linked, impacting overall health.
- Communication between these systems influences disease development and progression.
Purpose of the Study:
- To systematically review the molecular mechanisms of PNS modulation of immune cell function.
- To summarize advancements in targeting the neuroimmune axis for disease treatment.
Main Methods:
- Systematic analysis of molecular communication pathways.
- Review of neuroelectric stimulation and pharmacological strategies.
- Synthesis of findings on autonomic nervous system (ANS) and sensory neuron-immune interactions.
Main Results:
- PNS and immune system share ligands and receptors that coordinate responses.
- Neuroimmune circuits play a role in maintaining homeostasis and disease pathology.
Conclusions:
- The neuroimmune axis is a critical regulator of physiological balance and disease.
- Targeting neuroimmune circuits presents novel therapeutic opportunities for various diseases.
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