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Comparable 12-Week and Superior 24-Week Remission With Risankizumab vs Ustekinumab for Crohn's-Like Disease of the
Maia Kayal1, Darwin Jimenez1, Justin Huang1
1Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
Abstract:
Approximately 10% to 15% of patients with ulcerative colitis (UC) develop Crohn's-like disease of the pouch (CLDP) after restorative proctocolectomy with ileal pouch anal anastomosis∗.1,2 There are no therapies approved specifically for CLDP, and current guidelines recommend the use of advanced therapies approved more broadly for UC and Crohn's disease (CD) with reported remission rates of 40% to 60%.3 Comparative effectiveness data for these off-label therapies in CLDP is scarce, and optimal positioning is unknown. The head-to-head SEQUENCE trial demonstrated that risankizumab was noninferior to ustekinumab for clinical remission at week 24 and superior for endoscopic remission at week 48 in biologic-exposed patients with moderate-to-severe CD.4 Whether these results extend to patients with CLDP is unclear.
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