Incorporation and release of diclofenac sodium using chitosan chemically modified with glutaraldehyde and
Joelma Moreira Abreu1, Alisson de Jesus Santana1, Rejane Teixeira do Nascimento1
1Interdisciplinary Laboratory of Advanced Materials, Federal University of Piauí, Teresina, PI 64049-550, Brazil.
Abstract:
Diclofenac sodium (SD) is a widely used nonsteroidal anti-inflammatory drug (NSAID) with notable therapeutic relevance. In this study, chitosan was chemically modified with glutaraldehyde and ethylenediamine via a solvent-free synthesis route, aiming to develop an efficient and sustainable platform for drug adsorption and controlled release. The modified chitosan (MCGE) was thoroughly characterized by Fourier-transform infrared spectroscopy (FTIR), solid-state 13C nuclear magnetic resonance (NMR), thermogravimetric analysis (TGA), X-ray diffraction (XRD), and elemental analysis, confirming successful functionalization and enhanced thermal stability. Adsorption experiments conducted at pH 5 revealed a maximum diclofenac sodium uptake of 122.69 mg·g-1 within 90 min. Release studies demonstrated improved drug release at physiological pH (7.4), indicating favorable conditions for both gastrointestinal and systemic delivery. This study highlights the potential of MCGE as a biocompatible and thermally stable carrier for controlled drug delivery applications.
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