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The Relationship Between Psychedelic Use and Alcohol Use Disorder in a Nationally Representative Sample.

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|November 10, 2025
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Summary

Past-year LSD use was associated with lower odds of alcohol use disorder (AUD). Other psychedelics like MDMA and ketamine showed no significant association with AUD in this large-scale study.

Keywords:
AUDAlcoholLSDMDMAketaminepsilocybin

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Area of Science:

  • Psychiatry and Behavioral Sciences
  • Neuroscience
  • Public Health

Background:

  • Psychedelic-assisted therapies show promise for substance use disorders.
  • Research on naturalistic psychedelic use and alcohol consumption is limited.
  • Alcohol use disorder (AUD) affects a significant portion of the population.

Purpose of the Study:

  • To investigate the association between naturalistic psychedelic use and AUD.
  • To examine the impact of LSD, MDMA, and ketamine use on problematic alcohol consumption.
  • To analyze data from a nationally representative sample to understand these relationships.

Main Methods:

  • Utilized logistic regression and quasi-Poisson regression analyses.
  • Examined past-year use of LSD, MDMA, and ketamine in a sample of 139,524 individuals.
  • Controlled for demographic factors and comorbid substance use.

Main Results:

  • Past-year LSD use was significantly associated with lower odds of AUD (aOR=0.70, p=0.006).
  • LSD use was linked to 15.7% fewer AUD symptoms (IRR=0.84, p=0.033).
  • MDMA and ketamine use did not show significant associations with AUD or its symptoms.

Conclusions:

  • Findings suggest differential associations between specific psychedelics and AUD.
  • LSD use appears to be linked to a reduced risk of alcohol use disorder.
  • Further research is needed to explore the mechanisms underlying LSD's potential effects on alcohol use.