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Hyalase in Dermatology: Applications Beyond Filler Management
Saba Hasanzadeh1, Parisa Farokh1, Golsa Sadat Hosseini1
1Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Journal of Cosmetic Dermatology
|November 10, 2025
Summary
Hyaluronidase, an enzyme that degrades hyaluronic acid (HA), offers diverse therapeutic benefits beyond cosmetic filler dissolution. Its applications include enhancing drug delivery and treating dermatological conditions like keloids and scleroderma.
Area of Science:
- Dermatology
- Enzymology
- Pharmacology
Background:
- Hyaluronic acid (HA) is a crucial skin extracellular matrix component.
- Hyaluronidase enzymatically degrades HA, with FDA approval for specific medical uses.
- Its primary application involves dissolving HA fillers, but broader uses are emerging.
Purpose of the Study:
- To investigate hyaluronidase applications beyond common medical uses.
- To elucidate its mechanism in treating conditions like drug extravasation, scleroderma, scleromyxedema, and keloids.
Main Methods:
- A comprehensive literature review of hyaluronidase applications in medicine, focusing on dermatology.
- Databases searched include PubMed/MEDLINE, Cochrane Library, and Embase.
- Evaluation and summarization of application protocols for various conditions.
Main Results:
- Hyaluronidase enhances tissue permeability and drug delivery, aiding keloid treatment and chemotherapy distribution.
- It effectively reduces fibrosis in scleroderma, scleromyxedema, and chronic GVHD.
- Hyaluronidase is generally safe with infrequent adverse effects.
Conclusions:
- Hyaluronidase demonstrates significant potential for treating various medical and dermatological conditions.
- Further research is needed to address knowledge gaps and establish standardized protocols for its use.
