Construction of Spirocyclic Molecules from Cyclic β-Diketones
Ajeet Chandra1, Subba Rao Cheekatla2, Irishi N N Namboothiri3
1Department of Information Display, Kyung Hee University, Seoul, 02447, South Korea.
Chemical Record (New York, N.Y.)
|November 10, 2025
Summary
This review highlights efficient methods for creating spirocyclic molecules using cyclic 1,3-diketones. These compounds show promise for medicinal chemistry due to their anticancer and antimicrobial activities.
Area of Science:
- Organic Chemistry
- Medicinal Chemistry
Background:
- Spirocyclic molecules are important scaffolds in drug discovery.
- Efficient synthetic strategies are needed for their construction.
Purpose of the Study:
- To summarize recent advances in straightforward and efficient synthesis of spirocyclic molecules.
- To highlight the utility of cyclic 1,3-diketones as versatile synthons.
Main Methods:
- Review of one-pot, single-step, multistep, and multicomponent reactions.
- Utilization of cyclic 1,3-diketones with various partners (aldehydes, ketones, amines, isatins, acenaphthoquinone).
- Application of stoichiometric and catalytic conditions, including nanoparticle-supported catalysts.
Main Results:
- Development of efficient strategies for spirocycle construction.
- High yields achieved using various reaction conditions.
- Demonstration of the versatility of cyclic 1,3-diketones.
Conclusions:
- The reviewed methods offer practical routes to diverse spirocyclic frameworks.
- Spirocyclic compounds exhibit significant biological activities (anticancer, antimicrobial, antifungal).
- These molecules are promising candidates for drug development.
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