Construction of Spirocyclic Molecules from Cyclic β-Diketones
Ajeet Chandra1, Subba Rao Cheekatla2, Irishi N N Namboothiri3
1Department of Information Display, Kyung Hee University, Seoul, 02447, South Korea.
Abstract:
In this review, recently developed straightforward and efficient strategies for the construction of spirocyclic molecules are summarized. Cyclic 1,3-diketones serve as versatile synthons and can be employed in one-pot, single-step reactions as well as in multistep sequences and multicomponent processes with a variety of reacting partners, including aldehydes, ketones, amines, isatins, and acenaphthoquinone. These transformations can be facilitated either by using stoichiometric amounts of reagents or under catalytic conditions, including nanoparticle-supported systems, often resulting in significantly enhanced yields of the desired spirocycles. Some of the spirocyclic frameworks display a wide range of biological activities, showing efficacy against cancer, microbial, and fungal targets, and thus represent promising candidates for future medicinal chemistry and drug development.
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