Comparison of growth pattern in lung adenocarcinoma with L858R and 19DEL EGFR mutation

Mathematical comparisons of lung adenocarcinoma (LUAD) with epidermal growth factor receptor (EGFR) mutations of L858R and 19DEL.

A total of 1,980 surgically resected LUAD cases were analyzed, comprising 1,195 ground glass opacity LUAD (GGO-LUAD) and 785 pure solid lung adenocarcinomas (pSD-LUAD). LUAD cases were grouped based on EGFR mutation status. Correlations between tumor size (x) and frequency ratio (y) were analyzed using exponential equations.

Multivariate logistic regression analysis showed that the 19DEL mutation was more frequently observed in younger individuals (OR: 1.60, 95% CI: 1.29-1.99, p < 0.0001) and high-grade tumors (OR: 1.46, 95% CI: 1.01-2.11, p = 0.004). Equations were fitted as follows: y = e^{-0.046 + 0.48} × (x ≤ 2.5 cm, p = 0.0016) (1), y = e^{-2.09 + 0.37} × (x ≤ 4 cm, p < 0.0001) (2), y = e^{-1.65 + 0.38} × (x ≤ 4 cm, p = 0.0001) (3).

pGGO-LUAD with L858R EGFR mutations grew more rapidly than those with 19DEL mutations, but the solidification rate of L858R-mutated GGO-LUAD was lower compared to 19DEL-mutated GGO-LUAD.