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Published on: December 4, 2007
Baicalin protects retinal ganglion cells by regulating microglial polarization and ferroptosis via the JAK2/STAT3
Huan Yu1, Tianzhao Xu1, Qiaozong Feng2
1Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai, China.
Introduction:
This study investigated the protective effects of baicalin on retinal ganglion cells (RGCs) subjected to ischemia-reperfusion injury and explored the underlying mechanisms.
Methods:
By establishing an in vitro model of oxygen-glucose deprivation/reperfusion (OGD/R) in a microglia-RGC co-culture system, we examined the protective role of baicalin against RGC injury.
Results:
The results demonstrated that baicalin significantly suppressed the M1 polarization of microglia, promoted their shift toward M2 polarization, and alleviated oxidative stress and ferroptosis in RGCs by inhibiting the JAK2/STAT3 signaling pathway.
Conclusion:
This study reveals that baicalin protects RGCs by modulating microglial polarization and inhibiting ferroptosis, providing novel insights for the treatment of glaucoma.
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