Clinical course of severe congenital aortic valve stenosis in children
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View abstract on PubMed
Summary
This summary is machine-generated.Lifelong follow-up is crucial for children with severe congenital valvular aortic stenosis (VAS). Treatment pathways and outcomes vary significantly by age, necessitating further research into disease course determinants.
Area Of Science
- Pediatric Cardiology
- Congenital Heart Disease
- Valvular Heart Disease
Background
- Congenital valvular aortic stenosis (VAS) in children necessitates lifelong monitoring.
- A lack of age-specific treatment guidelines exists for severe pediatric VAS.
Purpose Of The Study
- To assess patient journeys and outcomes following a diagnosis of severe pediatric VAS.
- To describe the clinical course and treatment trajectories using a 37-year single-center experience.
Main Methods
- Retrospective collection of data for children diagnosed with severe congenital VAS between 1985 and 2022.
- Analysis of time-related mortality using the Kaplan-Meier estimator.
- Evaluation of intervention occurrence with the Aalen-Johansen estimator.
Main Results
- 245 children (median age 1.2 years) were diagnosed with severe VAS.
- 35-year incidence of death was 16.2%; 86.1% of patients underwent intervention.
- Balloon valvuloplasty was common in infants, while aortic valve replacement was more frequent in older children.
Conclusions
- Significant heterogeneity exists in treatment pathways and outcomes for pediatric severe VAS based on age at diagnosis.
- Disease stabilization or regression occurred in some children without intervention, highlighting the need for further research.
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