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The crosstalk between probiotics and T cell immunity.
Yuanyuan Liu1, Xu Cao2, Hongwei Liu1
1Institute of Biology, Hebei Academy of Sciences, Shijiazhuang, Hebei, China.
Frontiers in Immunology
|November 10, 2025
Summary
Probiotics significantly impact T cell responses, influencing immune homeostasis and disease prevention. Understanding this probiotic-T cell axis offers new therapeutic strategies for immune regulation.
Area of Science:
- Immunology
- Microbiology
- Gastroenterology
Background:
- Probiotic supplementation is a recognized health maintenance strategy.
- Probiotics show therapeutic potential in autoimmune diseases, metabolic disorders, and cancer immunotherapy.
- T cell mediated immune responses are crucial in various diseases.
Purpose of the Study:
- To elucidate the crosstalk between probiotic microorganisms and T cells.
- To explore how probiotics modulate T cell differentiation, activation, proliferation, and function.
- To reveal the potential of probiotics in immune regulation and disease prevention via the T cell axis.
Main Methods:
- Literature review focusing on T cell mediated responses and diseases.
- Analysis of experimental and mechanistic investigations on probiotics and T cells.
- Examination of probiotic modulation of CD4+ and CD8+ T cell subsets.
Main Results:
- Probiotics intricately crosstalk with T cells, influencing their subsets.
- Probiotics modulate key T cell functions, impacting immune response.
- The probiotic-T cell axis is a significant factor in immune homeostasis.
Conclusions:
- Understanding the probiotic-T cell interaction is vital for immune regulation.
- Probiotics hold promise for novel therapeutic strategies and preventive measures.
- Targeting the probiotic-T cell axis can advance treatments for immune-related conditions.
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