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Investigating Potential Biomarkers of Ankylosing Spondylitis: A Study on Mitochondrial and Senescence Pathways Using
Lu Yang1,2, Chitat Chang1, WengFai Tam3
1Faculty of Chinese Medicine, Macau University of Science and Technology, Macau, People's Republic of China.
Journal of Inflammation Research
|November 10, 2025
Summary
Researchers identified COX17 and MATK as key biomarkers linking mitochondrial dysfunction and cellular senescence in ankylosing spondylitis (AS). These findings offer potential for earlier disease detection and tailored treatments for AS patients.
Area of Science:
- Immunology
- Genetics
- Cell Biology
Background:
- Ankylosing spondylitis (AS) is a chronic inflammatory disease.
- Mitochondrial dysfunction and cellular senescence are implicated in AS progression.
Purpose of the Study:
- Identify novel biomarkers for ankylosing spondylitis.
- Link mitochondrial dysfunction and cellular senescence to AS pathogenesis.
Main Methods:
- Analyzed transcriptomic data from AS patients and controls.
- Utilized bioinformatics and machine learning to screen biomarkers.
- Validated findings in independent datasets and a mouse model.
Main Results:
- Identified differentially expressed mitochondrial and senescence-related genes in AS.
- COX17 and MATK emerged as significant diagnostic candidates.
- Validated COX17 and MATK in an AS mouse model, showing altered expression and osteogenic activity.
Conclusions:
- COX17 and MATK are promising biomarkers for ankylosing spondylitis.
- These biomarkers connect mitochondrial dysfunction and cellular senescence to AS.
- Potential for improved early detection and personalized therapies for AS.
