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Updated: Jan 11, 2026
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Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
An ortho-rhom-bic polymorph of isavuconazole
Anna Ben1,2, Lilianna Chęcińska2
1University of Lodz Doctoral School of Exact and Natural Sciences Narutowicza 68 90-136 Łódź Poland.
Abstract:
The title compound C22H17F2N5OS (systematic name: 4-{2-[(2R,3R)-3-(2,5-di-fluoro-phen-yl)-3-hy-droxy-4-(1,2,4-triazol-1-yl)butan-2-yl]-1,3-thia-zol-4-yl}benzo-nitrile), represents a new ortho-rhom-bic polymorph of isavuconazole. The two stereogenic centers adopt the R,R configuration. In the crystal structure of the ortho-rhom-bic form, a mono-periodic chain motif is formed by a strong O-H⋯N hydrogen bond, while three additional C-H⋯N inter-actions propagate these chains into a tri-periodic supra-molecular network. A comparison with the previously reported monoclinic polymorph [Voronin et al. (2021 ▸). CrystEngComm 23, 8513] is provided, supported by Hirshfeld surface and energy framework analyses.
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