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Bioinformatics driven in gene targeting platform for gold anticancer strategy delivery.

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|November 10, 2025
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Researchers identified SDC1 as a key gene in triple-negative breast cancer (TNBC), linking its high expression to poor survival and drug resistance. A novel gold nanocluster system targeting SDC1 effectively inhibited TNBC progression and angiogenesis.

Keywords:
Nucleic acid delivery systemSDC1Single-cell sequencingTriple-negative breast cancer

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Area of Science:

  • Oncology
  • Molecular Biology
  • Nanotechnology

Background:

  • Triple-negative breast cancer (TNBC) is highly aggressive with limited targeted therapies.
  • Current TNBC treatment relies heavily on chemotherapy, highlighting the need for novel therapeutic strategies.
  • Identifying specific molecular targets and effective delivery systems is crucial for advancing TNBC treatment.

Purpose of the Study:

  • To identify novel therapeutic targets in TNBC.
  • To develop an effective nucleic acid delivery system for TNBC treatment.
  • To elucidate the role of SDC1 in TNBC progression and drug resistance.

Main Methods:

  • Gene chip data screening to identify differentially expressed genes in TNBC.
  • Single-cell RNA sequencing (scRNA-seq) to analyze SDC1-dependent changes in the tumor microenvironment (TME).
  • Construction of an in situ self-reactive gold nanocluster SDC1 shRNA-targeted nucleic acid delivery system.

Main Results:

  • SDC1 was identified as a highly expressed gene in TNBC, correlating with poorer overall survival.
  • Increased SDC1 expression was associated with etoposide drug resistance in TNBC.
  • The developed gold nanocluster system effectively inhibited TNBC angiogenesis by targeting SDC1.
  • SDC1 was found to promote tumor progression via modulation of the TNBC microenvironment.

Conclusions:

  • SDC1 is a potential therapeutic target for TNBC, implicated in tumor progression and drug resistance.
  • A bioinformatics-driven platform can facilitate the rational design of nanocluster-based anticancer strategies.
  • Targeted nucleic acid delivery systems, like the gold nanocluster developed, show promise for inhibiting TNBC growth and angiogenesis.